Ebola Virus Disease (EVD) involves:
Viral Infection: Ebola virus infects human cells, particularly immune cells and endothelial cells.
Immune Response: The virus triggers a robust immune response, causing inflammation and tissue damage.
Dissemination: Ebola virus spreads rapidly in the body, affecting multiple organ systems.
Bleeding: Severe cases may lead to internal and external bleeding (hemorrhage) due to clotting dysfunction.
Complications: EVD can lead to multi-organ failure and death in severe cases.
Clinical Evaluation
Symptoms: Assessment of symptoms such as fever, headache, muscle pain, and gastrointestinal symptoms.
Physical Examination: Examination to assess signs of bleeding, shock, and organ dysfunction.
Diagnostic Tests: Ebola virus antigen or RNA detection through PCR, blood tests for liver and kidney function.
Fever, headache, muscle pain, and weakness.
Abdominal pain, vomiting, and diarrhea.
Internal and external bleeding in severe cases.
Shock, organ failure, and coma.
Management focuses on supportive care and symptom relief:
Fluid and Electrolyte Management: Intravenous fluids to maintain hydration and electrolyte balance.
Medications: Experimental antiviral drugs and supportive medications.
Infection Control: Isolation precautions to prevent transmission.
Research: Ongoing research for vaccines and specific treatments.